For a long time there was a view that pregnancy has a bad effect on the course of S. However, this was not supported by clear evidence. Nowadays, the results of studies are known to show that during pregnancy there is an attenuation of S activity (stabilisation of the disease and reduction and attenuation of the number of episodes), while the first trimester after delivery leads to an increase in the projective activity of the disease. Research is still ongoing into the role of female sex hormones in the course of S and the role of immunoprotective factors produced during pregnancy.

The most important issue to date remains the increase in the number of casts and their severity after delivery (usually three months after delivery). This was one very important factor in favour of women with S not having children. Of course, this is a very individual issue and not every woman necessarily has an increased and exacerbated incidence of casts after giving birth.

Studies have shown that a single pregnancy has no adverse effect on the development and rate of development of women with multiple sclerosis. Further research is underway to show that pregnancy may have a very beneficial distant effect on the development and rate of the disease.

Childbirth is dependent on the health status of the woman with S (degree of disability). Breastfeeding the born child, has no effect on the risk of a flare-up. It is very important that the children of mothers affected by S, develop normally and do not show any differences compared to the children of healthy mothers.

In the case of women affected by S, the key role is to talk to the patient, giving her all the information available about MS and pregnancy. However, the decision to have offspring should ultimately be made by the parents.