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In daily practice, there are situations where a single vaccine is recommended according to the vaccination calendar, but only combination vaccines with other antigens are available.

The first vaccination against tuberculosis is given to all newborns born in good condition on day 1 of life. The vaccine is given together with the hepatitis B vaccination.

The most common excessive (adverse) reaction after TB vaccination is an extensive, long-healing abscess at the vaccination site, or a significant reaction from the surrounding lymph nodes.