Among oncological treatments, chemotherapy is widely used. However, it is a method that, like many others, has its limitations. One of them is the organism's reaction called chemo-resistance, i.e. resistance to the administered drugs. As the human body has many resistance mechanisms, often this type of response is an interaction of many of them.

Resistance when chemotherapy is administered is cellular and biochemical in origin, meaning an impairment of the organism's ability to accumulate the drug in cells, to activate it within cells, or to enhance inactivation or repair processes in relation to drug-induced changes. Most such responses of the body are the result of changes in gene expression. Resistance may also be mediated by a natural barrier in the body, which in turn is an anatomical mechanism.[1]