This method is related to the transplantation of a heart, which is obtained from a dead donor. The operation is very complex and is carried out in specialised centres by qualified personnel.

Among the direct indications for heart transplantation are end-stage heart failure in cardiomyopathy, end-stage heart failure in advanced valvular defect and end-stage heart failure in ischaemic heart disease.

Heart transplantation significantly improves the heart's performance and thus the quality of life of the patient.